A Case of Hypopituitarism Complicated by Non-Alcoholic Steatohepatitis and Severe Pulmonary Hypertension
نویسندگان
چکیده
BACKGROUND Pulmonary arterial hypertension (PAH), which is caused by increased pulmonary artery pressure, results in right-heart failure and presents with shortness of breath, chest pain, syncope. PAH has idiopathic, heritable, drug/toxin causes accompanied other conditions, including connective tissue disease, congenital heart portal hypertension. Rarely, a type called portopulmonary (POPH). Portal can be triggered liver cirrhosis, result from non-alcoholic steatohepatitis (NASH), metabolic syndrome hypopituitarism. Although an association between hypopituitarism POPH been suggested, few reports have described this relationship. CASE REPORT A 43-year-old woman received hormone replacement therapy after partial hypothalamic resection at age 4 years. At 32 years, she developed cirrhosis NASH due to adult growth (GH) deficiency. Despite restarting GH therapy, refused the required doses for economic reasons. She was hospitalized abdominal pain dyspnea found severe POPH. PAH-specific therapies, endothelin receptor antagonist prostacyclin analog. improved on day 3 hospitalization while cardiac index gradually. On 12, her respiratory status rapidly worsened percutaneous cardiopulmonary support applied. 18, died multiple organ disseminated intravascular coagulation despite intensive care management. CONCLUSIONS Severe PAH, particularly POPH, remains incurable use therapies For patients, careful observation, system, improve prognosis completing therapy.
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ژورنال
عنوان ژورنال: American Journal of Case Reports
سال: 2021
ISSN: ['1941-5923']
DOI: https://doi.org/10.12659/ajcr.928004